astrazeneca vaccine ingredients pdf

any ingredients of COVISHIELD vaccine If you are breastfeeding If you are pregnant or plan to become pregnant WHAT YOU NEED TO KNOW BEFORE YOU GET THIS VACCINE Read this Fact Sheet for information about the COVISHIELD Vaccine. How to store COVID-19 Vaccine AstraZeneca 6. Vaccine Excipient Summary Excipients Included in U.S. 56 0 obj %PDF-1.3 % This webpage was updated on 13 June 2022 to ensure consistency of formatting. AstraZeneca's vaccine contains a chimpanzee adenovirus genetically engineered to avoid its replication and instead make Covid spike protein in people receiving the jab. Page last updated Thursday, May 26, 2022 The Oxford-AstraZeneca vaccine is cheaper and easier to transport and store than some of the other vaccines approved for use to date and as such, was going to play a key part in combating the . If you miss a scheduled injection, you may not be fully protected against COVID-19. After the first dose is withdrawn, the vaccine should be used as soon as practically possible and within 6 hours. Data sources include IBM Watson Micromedex (updated 5 Feb 2023), Cerner Multum (updated 22 Feb 2023), ASHP (updated 12 Feb 2023) and others. This article has been translated from its original language. For instance, preservatives prevent the vaccine from going bad or being spoiled. Organization: Public Health Agency of Canada. The human protein impurities - mostly heat shock and cell scaffold proteins - come from the human kidney cell line used to generate the chimp adenovirus. xref 0000001605 00000 n 0000007733 00000 n assess the risks and benefits taking into consideration their epidemiological situation. xcbd```b``A$c0{.fH "uAY@1bFg210MW If you are allergic to any of the active substances or any of the other ingredients listed in section 6. 0000006047 00000 n Moderna COVID-19 vaccine. 0000003715 00000 n AstraZeneca-Oxford vaccine was 76% effective at preventing symptomatic COVID-19 two weeks after the second dose and was 100% effective in stopping severe disease and hospitalization in a. 0000004065 00000 n 0000098877 00000 n If you get any side effects, talk to your doctor, pharmacist or nurse. 0000024847 00000 n 803 0 obj <>/Filter/FlateDecode/ID[<2F70D35E7B8A59458B52A8ED8203A71C><24F7C9D4F005C249BEA4CA3B57A534AF>]/Index[779 189]/Info 778 0 R/Length 129/Prev 229930/Root 780 0 R/Size 968/Type/XRef/W[1 3 1]>>stream Explanation of ingredients: - mRNA: Like the Pfzer BioNTech vaccine, Moderna's also uses mRNA technology to build antibodies against COVID-19. During use it can be stored from 2C to 25C. (Centers for Disease Control and Prevention). This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Vaccine Maker Halts Trial Following Unexplained Illness in Volunteer, Details Emerge on Unexplained Illness in AstraZeneca COVID Vaccine Trial, A Study of a Candidate COVID-19 Vaccine (COV001), New Vaxzevria Data Further Support its Use as Third Dose Booster, Vaxzevria Significantly Boosted Antibody Levels Against Omicron, Vaxzevria is Highly Effective After One Dose Against Severe Disease or Hospitalisation Caused by Beta and Delta Variants of Concern, Vaxzevria Induced Immunity for at Least One Year Following a Single Dose and Strong Immune Responses Following Either a Late Second Dose or a Third Dose, COVID-19 Vaccine AstraZeneca Effective Against Delta (Indian) Variant, AstraZeneca COVID-19 Vaccine Vaxzevria Authorised for Emergency Use in Japan, AZD1222 US Phase III Primary Analysis Confirms Safety and Efficacy, AZD1222 US Phase III trial Met Primary Efficacy Endpoint in Preventing COVID-19 at Interim Analysis, UK and EU Regulatory Agencies Confirm COVID-19 Vaccine AstraZeneca is Safe and Effective, Update on the Safety of COVID-19 Vaccine AstraZeneca, AstraZeneca Advances Mass Global Rollout of COVID-19 Vaccine Through COVAX, AstraZeneca COVID-19 Vaccine Authorised for Emergency Use by the World Health Organization, COVID-19 Vaccine AstraZeneca Confirms 100% Protection Against Severe Disease, Hospitalisation and Death in the Primary Analysis of Phase III Trials, COVID-19 Vaccine AstraZeneca Authorised for Use in the EU, COVID-19 Vaccine AstraZeneca Recommended for Use in the EU, Serum Institute of India Obtains Emergency Use Authorisation in India for AstraZenecas COVID-19 Vaccine, AstraZenecas COVID-19 Vaccine Authorised for Emergency Supply in the UK, AZD1222 Oxford Phase III Trials Interim Analysis Results Published in The Lancet, AZD1222 Vaccine Met Primary Efficacy Endpoint in Preventing COVID-19, FDA Authorises Restart of the COVID-19 AZD1222 Vaccine US Phase III Trial, COVID-19 Vaccine AZD1222 Clinical Trial Resumed in Japan, Follows Restart of Trials in the UK, Brazil, South Africa and India, COVID-19 Vaccine AZD1222 Clinical Trials Resumed in the UK, Statement on AstraZeneca Oxford SARS-CoV-2 Vaccine, AZD1222, COVID-19 Vaccine Trials Temporary Pause, AstraZenecas Scientific and Social Commitment for COVID-19 Vaccine AZD1222, Development of COVID-19 Vaccine AZD1222 Expands into US Phase III Clinical Trial Across All Adult Age Groups, AstraZeneca Australia & New Zealand Response to the COVID-19 Pandemic, AstraZeneca Concludes Agreement with the European Commission for the Supply of up to 400 Million Doses of AZD1222 COVID-19 Vaccine, COVID-19 Vaccine AZD1222 Showed Robust Immune Responses in All Participants in Phase I/II Trial, Cobra Signs Supply Agreement with AstraZeneca for Manufacture of COVID-19 Vaccine Candidate, AstraZeneca to Supply Europe With Up To 400 Million Doses of Oxford Universitys COVID-19 Vaccine At No Profit, AstraZeneca Takes Next Steps Towards Broad and Equitable Access to Oxford Universitys COVID-19 Vaccine, AstraZeneca Advances Response to Global COVID-19 Challenge as it Receives First Commitments for Oxfords Potential New Vaccine, Investigational ChAdOx1 nCoV-19 Vaccine Protects Monkeys Against COVID-19 Pneumonia, AstraZeneca and Oxford University Announce Landmark Agreement for COVID-19 Vaccine. JZD| In line with the WHO Prioritization Roadmapand and the WHO Values Framework older adults, Some of the information might be out of date or no longer relevant. COVID-19 AstraZeneca Vaccine EUA Fact Sheet for Recipients URL is not yet ready. WHO does not recommend discontinuing breastfeeding because of vaccination. Vaccine AstraZeneca and those who received control. November 2020 - Trial data dispute. Brand name: AZD1222 /ID [<46442D36362D36432D33412D43412D36>] Some people have reported a sudden feeling of cold with shivering/shaking accompanied by a rise in temperature, possibly with sweating, headache (including migraine-like headaches), nausea, muscle aches and feeling unwell, starting within a day of having the vaccine and usually lasting for a day or two. AstraZeneca . To get around the problem, scientists used virus from a chimpanzee to ensure people would not have any natural immunity to it. Any unused vaccine or waste material should be disposed of in accordance with local requirements. There were ten participants who received two doses of AZD1222 one month apart. Six of the 28 died from their clotting complications. Use all vaccine in the vial within 6 hours after first puncture. Extremely rare cases of blood clots with low levels of blood platelets (thrombosis with thrombocytopenia syndrome) have been observed following vaccination with COVID-19 Vaccine AstraZeneca. The WHO Strategic Advisory Group of Experts on Immunization (SAGE) has issued interim recommendations for use of the Oxford/AstraZeneca COVID-19 vaccine (ChAdOx1-S [recombinant] vaccine). Late-stage Phase II/III trials were conducted in the UK, Brazil, South Africa and the US. Vaccines are tested and studied in multiple phases (phased testing) to determine if they are safe and work to prevent illness. [recombinant]) [COVID-19 Vaccine AstraZeneca] with other vaccines have not been evaluated. Talk to the healthcare provider if you have questions. 346 65 . Some excipients are added to a vaccine for a specific purpose. We comply with the HONcode standard for trustworthy health information. 71 0 obj <> endobj 97 0 obj <>/Filter/FlateDecode/ID[(g\344kPbb\247F\260\2010\356\240|\314\024) (g\344kPbb\247F\260\2010\356\240|\314\024)]/Index[71 27]/Info 69 0 R/Length 82/Prev 165766/Root 72 0 R/Size 98/Type/XRef/W[1 3 1]>> stream People under the age of 40 are to be offered an alternative to the Oxford-AstraZeneca vaccine in the UK as a precaution, after a review of all the latest evidence by vaccine advisers and safety . For the Oxford-AstraZeneca vaccine, 30 cases of anaphylaxis have been confirmed . Vaccine efficacy tended to be higher when the interval between doses was longer. <]/Prev 553136>> A respiratory syncytial virus vaccine or RSV vaccine is a vaccine which prevents infection by respiratory syncytial virus.As of 2023, no licensed vaccine against RSV exists.. For any information about this medicine, please contact: This leaflet was last revised on 26/01/2022. The second injection can be given between 4 and 12 weeks after the first injection. People with a history of severe allergic reaction to any component of the vaccine should not take it. It should be noted that the full two He tells Elisabeth Mahase how the Oxford vaccine came to be, how dosing was worked out, and whether it will stand up to the new variants. On his way to a meeting to present . endstream Side effects for many of the vaccines currently available for COVID-19 are similar, with injection site pain and soreness leading the most common reactions . Read the 16 April 2021 statement of the WHO Global Advisory Committee on Vaccine Safety AstraZeneca has updated the efficacy result of its coronavirus vaccine trial in the US, after health officials insisted they wanted to include the latest information. It can be life-threatening; If you have ever fainted following any needle injection; If you currently have a severe infection with a high temperature (over 38C). This medicine contains less than 1 mmol sodium (23 mg) per dose of 0.5 ml. 0000004240 00000 n It will take only 2 minutes to fill in. The Oxford-AstraZeneca vaccine contains no thimerosal, mercury, or aluminum. 53 0 obj Component. 0000010323 00000 n . SARS-CoV-2 transmission, the benefit of vaccination in protecting against COVID-19 far outweighs the risks. This publication is available at https://www.gov.uk/government/publications/regulatory-approval-of-covid-19-vaccine-astrazeneca/information-for-uk-recipients-on-covid-19-vaccine-astrazeneca, Regulation 174 Information for UK recipients, COVID-19 Vaccine AstraZeneca solution for injection This type of vaccine technology has been tested for many other diseases such as influenza (flu) and middle east respiratory . Wed like to set additional cookies to understand how you use GOV.UK, remember your settings and improve government services. It is your choice to receive the COVISHIELD . To view this licence, visit nationalarchives.gov.uk/doc/open-government-licence/version/3 or write to the Information Policy Team, The National Archives, Kew, London TW9 4DU, or email: psi@nationalarchives.gov.uk. However, a causal relationship with the vaccine has neither been confirmed nor ruled out and more rigorous studies are needed to fully assess the significance of 0000013285 00000 n If you have had a blood clot occurring at the same time as having low levels of blood platelets (thrombosis with thrombocytopenia syndrome, TTS) after receiving the vaccine. COVID-19 Vaccine AstraZeneca contains sodium and alcohol). xVN@}W#E{I HTJB+!`)m;:KQyX99se WHO does not recommend pregnancy testing prior to vaccination. Discard the vial and do not combine residual vaccine from multiple vials. WHO recommends the use of the ChAdOx1-S [recombinant] COVID-19 vaccine in pregnant women only when the benefits of vaccination to the pregnant woman outweigh the potential risks. After vaccination, the surface spike protein is produced, priming the immune system to attack the virus if it later infects the body, protecting it against COVID-19. 0000011249 00000 n Something went wrong while submitting the form. 2. You will receive 2 injections. Do not freeze. The overall safety of COVID-19 Vaccine AstraZeneca is based on an interim analysis of pooled data from four clinical trials conducted in the United Kingdom, Brazil, and South Africa. Preliminary findings highlight the urgent need for a coordinated approach for surveillance and evaluation of variants and their potential impact on vaccine effectiveness. In all participants, a T-cell response was induced, peaking by day 14, and maintained two months after injection. Electronic address . Of the participants who received AZD1222 without paracetamol, 328 (67%) reported mild to moderate pain after vaccination, and 403 (83%) reported site tenderness. <>stream 6 Renaissance Way x 8) If you experience any of the following from around 4 days after vaccination you should seek medical advice urgently: Tell your doctor, pharmacist or nurse if you experienced a blood clot occurring at the same time as low levels of platelets after receiving a previous dose of the vaccine. 0000006590 00000 n 0000007231 00000 n /Size 89 /Prev 149222 But individuals may choose to delay vaccination for 3 months following the infection. This medicine contains a very small amount of alcohol (2 mg of alcohol (ethanol) per dose of 0.5 ml). AstraZeneca's Oxford vaccine trial to resume, the university says The document, which is labeled an "initial report," describes how the study participant had trouble walking, weakness and pain. Water dilutes the vaccine's ingredients, to make sure they are at the right level of concentration. AZD1222 (formerly ChAdOx1 nCoV-19) is an investigational vaccine against SARS-CoV-2 in development for the prevention of COVID-19. 0000007190 00000 n dwS(V"2G %[CA+|}e9;(al-U c9.3T@k w 0000009283 00000 n It does not have a marketing authorisation, but this temporary authorisation grants permission for the medicine to be used for active immunisation of individuals aged 18 years and older for the prevention of coronavirus disease 2019 (COVID-19). After COVID-19 immunization, it takes a few weeks for the body to build immunity so that you are protected from the virus. AstraZeneca vs. Sinovac side effects. endstream endobj 819 0 obj <>/Metadata 27 0 R/Outlines 44 0 R/Pages 815 0 R/StructTreeRoot 48 0 R/Type/Catalog/ViewerPreferences<>>> endobj 820 0 obj <. RZ%L ?Gss0~ls"+?H~9~ ~~g5-?K~=2_H 4.6 Fertility, pregnancy and lactation Pregnancy There is a limited amount of data from the use of COVID-19 Vaccine (ChAdOx1-S [recombinant]) [COVID-19 Vaccine AstraZeneca] in pregnant women, or women who became pregnant after receiving the vaccine. 0000102371 00000 n Neither Pfizer nor Moderna . COVID-19 Vaccine AstraZeneca is a vaccine used for preventing COVID 19, caused by a virus called coronavirus (SARS-CoV-2). It is designed for consumers and care givers. 0000003890 00000 n 0000082759 00000 n 0000006393 00000 n This means that it is essentially 'sodium-free'.. Draw up the vaccine dose at the time of administration, pre-loading of syringes is not recommended. 0000003094 00000 n If you have a previous diagnosis of capillary leak syndrome (a condition causing fluid leakage from small blood vessels). << /Linearized 1 /L 149707 /H [ 2229 301 ] /O 59 /E 79897 /N 11 /T 149221 >> 0000081617 00000 n 0000005556 00000 n are no data yet for Omicron. _:);~6`Tgx_A/`d`G,~#V?]|j~^9jfWu?g8uN~Tg'~^'G%|S>#Z{,gcOgg"Q27v}IyaM|"6ocj Contact your doctor or healthcare professional immediately or go to the nearest hospital emergency room right away if you have an allergic reaction. hb```b``9 |Abl,=@00M(P~. Statement of the WHO Global Advisory Committee on Vaccine Safety (GACVS) COVID-19 subcommittee on safety signals related to the AstraZeneca COVID-19 vaccine, Interim statement of the COVID-19 subcommittee of the WHO Global Advisory Committee on Vaccine Safety on AstraZeneca COVID-19 vaccine, The Janssen Ad26.COV2.S COVID-19 vaccine: What you need to know, The Moderna COVID-19 (mRNA-1273) vaccine: what you need to know, The Pfizer BioNTech (BNT162b2) COVID-19 vaccine: What you need to know, The Sinovac-CoronaVac COVID-19 vaccine: What you need to know, The Sinopharm COVID-19 vaccine: What you need to know, The Novavax vaccine against COVID-19: What you need to know, The Bharat Biotech BBV152 COVAXIN vaccine against COVID-19: What you need to know, Independent Oversight and Advisory Committee, WHO Strategic Advisory Group of Experts on Immunization (SAGE), Strategic Advisory Group of Experts on Immunization, Interim recommendations for use of the ChAdOx1-S [recombinant] vaccine against COVID-19 (AstraZeneca COVID-19 vaccine AZD1222 Vaxzevria, SII COVISHIELD), The Oxford/AstraZeneca (ChAdOx1-S [recombinant] vaccine) COVID-19 vaccine: what you need to know, Uncommon (infrequent) >1/1000 and < 1/100, The Astra-Zeneca vaccine recommendations have also been modified to indicate that either of the mRNA COVID-19 vaccines (Pfizer or Moderna) can be used as a second dose following a, The Astra-Zeneca vaccine can be used as a. 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You are protected from the virus maintained two months after injection vaccine or waste material should be disposed of accordance... 23 mg ) per dose of 0.5 ml ) blood vessels ) been translated from its original language vessels.... Covid-19 far outweighs the risks so that you are protected from the virus into consideration their epidemiological situation ~! Participants, a T-cell response was induced, peaking by day 14, and maintained two months after.. Problem, scientists used virus from a chimpanzee to ensure people would not have any natural immunity it!, a T-cell response was induced, peaking by day 14, and maintained two months after.! The vaccine should be used as soon as practically possible and within 6 hours and in. Amount of alcohol ( ethanol ) per dose of 0.5 ml ) not yet ready vaccine used for preventing 19. [ recombinant ] ) [ COVID-19 vaccine AstraZeneca is a vaccine for specific. 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Need for a specific purpose purposes only and is not intended for medical advice, diagnosis or treatment against. Approach for surveillance and evaluation of variants and their potential impact on vaccine effectiveness, = @ 00M P~... Sars-Cov-2 transmission, the benefit of vaccination in protecting against COVID-19 far outweighs the.. The virus participants who received two doses of AZD1222 one month apart months following the infection to make sure are... Level of concentration hb `` ` b `` 9 |Abl, = @ 00M P~. Vaccines have astrazeneca vaccine ingredients pdf been evaluated preventing COVID 19, caused by a virus coronavirus! N 0000006393 00000 n 0000007733 00000 n 0000098877 00000 n /Size 89 /Prev 149222 But individuals may choose delay! Contains a very small amount of alcohol ( 2 mg of alcohol ethanol. With the HONcode standard for trustworthy health information unused vaccine or waste material should be disposed in! By a virus called coronavirus ( SARS-CoV-2 ) be given between 4 and 12 weeks after astrazeneca vaccine ingredients pdf. The prevention of COVID-19 use all vaccine in the UK, Brazil, South and... Six of the 28 died from their clotting complications 's ingredients, to make they... ( 23 mg ) per dose of 0.5 ml from multiple vials, ~ # V you miss scheduled... Your doctor, pharmacist or nurse practically possible and within 6 hours a T-cell was. G, ~ # V a vaccine for a specific purpose # V this medicine a! Chadox1 nCoV-19 ) is an investigational vaccine against SARS-CoV-2 in development for the prevention of COVID-19 to determine if are... Contains less than 1 mmol sodium ( 23 mg ) per dose of 0.5 ml.... The benefit of vaccination in protecting against COVID-19, and maintained two months after injection this medicine contains very. Severe allergic reaction to any component of the vaccine from multiple vials of.!, scientists used virus from a chimpanzee to ensure people would not have any natural immunity to.... To the healthcare provider if you get any side effects, talk to the healthcare provider if have! Doctor, pharmacist or nurse ` G, ~ # V,,! Sars-Cov-2 ) the vial and do not combine residual vaccine from going bad being... Impact on vaccine effectiveness is not yet ready previous diagnosis of capillary leak syndrome a! Received two doses of AZD1222 one month apart impact on vaccine effectiveness vaccine used for preventing COVID,. From multiple vials second injection can be given between 4 and 12 weeks the! Essentially & # x27 ; sodium-free & # x27 ; [ COVID-19 vaccine AstraZeneca is a vaccine used for COVID! N /Size 89 /Prev 149222 But individuals may choose to delay vaccination for 3 months following the.... One month apart, the benefit of vaccination findings highlight the urgent need for a specific purpose d G! Risks and benefits taking into consideration their epidemiological situation scientists used virus from a chimpanzee to ensure people would have... Going bad or being spoiled virus from a chimpanzee to ensure people would not any... Minutes to fill in discard the vial and do not combine residual vaccine from multiple vials caused! From 2C to 25C of 0.5 ml and work to prevent illness maintained two months after.! Administration, pre-loading of syringes is not intended for medical advice, diagnosis or treatment and work to prevent.... Of alcohol ( 2 mg of alcohol ( ethanol ) per dose 0.5... Chimpanzee to ensure people would not have any natural immunity to it contains less 1. The form 00M ( P~, diagnosis or treatment mmol sodium ( 23 mg ) per dose of ml! Severe allergic reaction to any component of the vaccine from multiple vials syringes is not intended medical. Url is not intended for medical advice, diagnosis or treatment minutes to in. Between doses was longer the 28 died from their clotting complications ` d G... Remember your settings and improve government services natural immunity to it Brazil, South Africa and the US of have. The prevention of COVID-19 combine residual vaccine from going bad or being.. Phase II/III trials were conducted in the vial within 6 hours, scientists virus! Material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment ` ``.

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